TABLE 5.
β-Amyloid Pathology (4G8) in Military Early-Onset Dementia Cases
| Case #1 |
Case #2 |
Case #3 |
Case #4 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Left | Right | Bi-hem/Sym | Left | Right | Bi-hem/Sym | Left | Right | Bi-hem/Sym | Left | Right | Bi-hem/Sym | |
| OB | N/A | N/A | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | |
| MFG | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse-plaques (including MW) | Freq diffuse-plaques (including WM) | Yes/Yes | Neg | Neg | Yes/Yes |
| OFG | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and Mod cored-plaques | Freq diffuse- and Mod cored-plaques | Yes/Yes | Freq diffuse-plaques (including MW) | Freq diffuse-plaques (including WM) | Yes/Yes | Neg | Neg | Yes/Yes |
| MTC | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse-plaques (including MW) | Freq diffuse-plaques (including WM) | Yes/Yes | Neg | Neg | Yes/Yes |
| ACC | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| PCC | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| AInsC | Freq diffuse- and cored-plaques | Freq diffuse- and cored-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| OC | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- rare cored-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| AMY | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| BGMY | Mod diffuse-plaques | Mod diffuse-plaques | Mod diffuse-plaques | Mod diffuse-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes | |
| MAM+HYPO | Sparse diffuse-plaques | Sparse diffuse-plaques | Yes/Yes | Rare diffuse-plaques | Rare diffuse-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| PH+EC+ITC | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse- and rare cored-plaques | Freq diffuse- and rare cored-plaques | Yes/Yes | Freq diffuse-plaques | Freq diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| MESSN | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | Rare diffuse-plaques | Rare diffuse-plaques | Yes/Yes | Neg | Neg | Yes/Yes |
| PONS | Neg | Neg | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | |
| MObl | Neg | Neg | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | Neg | Neg | Yes/Yes | |
The table describes the β-amyloid (βA) pathology findings for each early-onset dementia (EOD) case as assessed by the antibody for 1–42 βA used in this study (4G8). The neuropathologic diagnoses were performed on 15 different neuroanatomical regions from both left and right hemisphere. Freq, frequent lesions (>6 per microscopic field at 20×); Mod, moderate lesions (2–6 per microscopic field at 20×); Sparse, sparse lesions (1–2 per microscopic field at 20×); Rare, rare lesions (1 per microscopic field at 20×).
OB, olfactory bulb; MFG, middle frontal gyrus; OFG, orbito-frontal gyrus/gyrus rectus; MTC, middle temporal cortex; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; AInsC, anterior insular cortex; OC, occipital cortex (BA17 and 18); AMY, amygdala; BGMY, basal ganglia; MAM+HYPO, mammillary bodies+hypothalamus; PH+EC+ITC, posterior hippocampus (at CGL) including entorhinal cortex and inf. temp cortex; MESSN, Mesencephalon (including substantia nigra); PONS, pons (including locus coeruleus [LC]); MObl, medulla oblongata (including dorsal motor of vagus).