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. 2020 Jan 17;16:1744806919900814. doi: 10.1177/1744806919900814

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Effects of AXL inhibitor TP0903 on CCD-induced nociceptive hypersensitivities. The dose of TP0903 (0.05, 0.5, or 1 μg) or vehicle solution was intrathecally administered 1 h before CCD or sham surgery and once daily for five days after CCD or sham surgery. The doses of 0.5 and 1 μg inhibited (a) the decrease of PWTs to mechanical stimulation, (b) PWLs to thermal stimulation, and (c) positive response latencies to cold stimulation on the ipsilateral side of CCD rats. N = 6 rats/group. Two-way repeated measure ANOVA (effect vs. group × time interaction) followed by post hoc Tukey tests, **P < 0.01 versus the corresponding time point in the Sham + Veh group. ^##P < 0.01 versus the corresponding time point in the CCD + Veh group. PWT: paw-withdrawal threshold; PWL: paw-withdrawal latency; CCD: chronic compression of dorsal root ganglion.