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. 2020 Jan 17;16:1744806919900814. doi: 10.1177/1744806919900814

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — Effect of AXL siRNA on CCD-induced nociceptive hypersensitivities. All siRNAs (10 μM in 10 μL vehicle solution) or vehicle solutions were intrathecally administered from day 3 to day 7 once daily for five days. Intrathecal injection of AXL siRNA (Si) but not NC siRNA reversed the decrease of PWTs to mechanical stimulation (a), PWLs to thermal stimulation (b), or positive response latencies to cold stimulation (c) on the ipsilateral side of CCD rats. N = 6 rats/group. Two-way repeated measure ANOVA (effect vs. group × time interaction) followed by post hoc Tukey tests. **P < 0.01 versus the corresponding time point in the Sham + Veh group. ^##P < 0. 01 versus the corresponding time point in the CCD + Veh group. NC: negative control; PWT: paw-withdrawal threshold; PWL: paw-withdrawal latency; CCD: chronic compression of dorsal root ganglion; siRNA: small interfering RNA.