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. 2020 Jan 17;16:1744806919900814. doi: 10.1177/1744806919900814

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Mediation by the intracellular signaling molecule, mTOR, of nociceptive effects of AXL. (a) The protein amount of p-mTOR and total mTOR increased in the ipsilateral L4/L5 DRGs on days 7 and 14 after CCD surgery. N = 3 rats/time point. One-way ANOVA (expression vs. time points) followed by post hoc Tukey test, *P < 0.05, **P < 0.01 versus day 0 (sham group). Repeatedly intrathecal injection of (b) TP0903 (1 μg) or (c) AXL siRNA (Si, 5 μM in 10 μL vehicle solution) reduced mTOR expression in compressed DRGs of CCD rats. N = 3 rats/time point. One-way ANOVA (effect vs. the treated groups) followed by post hoc Tukey tests, *P < 0.05, **P < 0.01, versus the Sham + Veh group; ^##P < 0.01 versus the CCD + Veh group. DRG: dorsal root ganglion; CCD: chronic compression of DRG; mTOR: mammalian target of rapamycin.