Table 3.
The effects of AM on pro- and antioxidation factors in the liver of mice with chronic alcohol injury.
| CTRL | Alcohol | ||||
|---|---|---|---|---|---|
| Model | Sil (63 mg/kg) | AM (0.5 g/kg) | AM (2 g/kg) | ||
| MDA (nmol/mg) | 3.9 ± 0.15 | 4.5 ± 0.18# | 3.6 ± 0.19∗ | 3.8 ± 0.11∗ | 3.7±0.04∗∗ |
| ROS (U/mg) | 32.1 ± 1.5 | 42.7 ± 1.3## | 35.1±1.1∗∗ | 35.3 ± 1.6∗ | 33.1±0.7∗∗ |
| CAT (U/mg) | 0.39 ± 0.09 | 0.15 ± 0.04### | 0.21±0.08∗∗ | 0.19±0.02∗∗ | 0.31±0.03∗∗∗ |
| SOD (U/mg) | 9.0 ± 1.3 | 4.1 ± 0.4### | 5.8 ± 0.3∗ | 5.4 ± 0.3∗ | 7.6±0.7∗∗ |
| GSH-PX (U/mg) | 15.9 ± 1.7 | 7.9 ± 1.1### | 18.8±2.0∗∗∗ | 11.6 ± 0.7∗ | 20.1±1.9∗∗∗ |
| CoQ3 (U/g) | 16.9 ± 0.5 | 15.1 ± 0.6# | 15.6 ± 0.7 | 17.2 ± 0.8∗ | 18.3±0.3∗∗ |
| MGST3 (U/g) | 115.2 ± 2.1 | 103.4 ± 1.8# | 111.4 ± 2.8∗ | 124.7±1.9∗∗∗ | 125.1±4.1∗∗∗ |
| APCS (ng/mg) | 123.8 ± 4.5 | 150.2 ± 6.2## | 95.4±2.9∗∗∗ | 162.8 ± 4.4 | 115.5±3.6∗∗ |
| CYP8B1 (ng/mg) | 1.21 ± 0.04 | 1.43 ± 0.05## | 0.93±0.02∗∗∗ | 1.43 ± 0.05 | 1.14±0.04∗∗ |
All date are presented as mean ± S.E.M. (n = 10). #p < 0.05, ##p < 0.01, and ###p < 0.001 compared with the control group; ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 compared with the alcohol-only treated model group.