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. 2019 Dec 24;8:e48890. doi: 10.7554/eLife.48890

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© 2019, Tomek et al

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Figure 1. — (A) A schematic of the novel human ventricular myocyte model for electrophysiology and calcium handling. Orange indicates components, substituted, or added, compared to the original ORd model. ‘SS’ indicates junctional subspace compartment, where calcium influx via L-type calcium current occurs and where calcium is released from the sarcoplasmic reticulum. ‘JSR’ and ‘NSR’ are junctional and network sarcoplasmic reticulum compartments, respectively. ‘Main cytosolic pool’ is the remaining intracellular space. Transmembrane currents are indicated with an ‘I’ in their name, with fluxes indicated as ‘J’. Components with a green underscore are modulated by CaMKII signalling. (B) The structure of the Lu-Vandenberg (Lu et al., 2001) Markov model used for the rapidly activating delayed rectifier repolarisation current (I_Kr). The transition rates are given in Appendix 1-15.3.5.