Appendix 1—table 2. Effect of BaCl2 on APD90 in experiments and simulations using the ToR-ORd model with different degrees of IK1 and IKr block.
Basic cycle length | Experimental data (O'Hara et al., 2011) | Simulated 90% IK1 block | Simulated 90% IK1 + 15% IKr block | Simulated 90% IK1 + 30% IKr block |
---|---|---|---|---|
500 ms | 271 (±50) ms | 250 ms | 271 ms | 297 ms |
1000 ms | 306 (±50) ms | 281 ms | 307 ms | 341 ms |
2000 ms | 361 (±50) ms | 286 ms | 311 ms | 342 ms |