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. 2019 Oct 25;8:e51230. doi: 10.7554/eLife.51230

Figure 8. The HCoV-229E S-protein shows a large opening in the S2 region.

Figure 8.

(a,b) Bottom views of the S-protein trimer at two contour levels showing the opening in S2 at (a) 1.5 RMS and (b) 3.0 RMS. The three S2 subunits are colored differently in (b). (c, d) Comparison of the 229E (teal) and NL63 (magenta) S2 core helices. (c) Bottom view. (d) Side view, with only one subunit colored. Each 229E S2 subunit rotates ~11° relative to the NL63 S2 subunit. Red arrows indicate the rotation axes around which each monomer rotates.