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. 2019 Dec 2;10(12):e00093. doi: 10.14309/ctg.0000000000000093

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 2. — Promoter methylation level of the Sox10 gene in IND. In the peripheral blood, the promoter methylation level at the 32nd locus of the Sox10 promoter was (a) 100% (90%–100%) in the control, (c) 90% (80%–90%) in HD, and (e) 60% (50%–80%) in IND. In colon specimens, the 32nd locus of the Sox10 gene promoter was (b) completely methylated in the control (80%; range, 80%–90%), (d) moderately methylated in the aganglionic segment in HD (80%; range, 80%–90%), and (f) hypomethylated in IND (60%; range, 50%–70%). HD, Hirschsprung disease; IND, intestinal neuronal dysplasia.