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. 2019 Dec 2;10(12):e00093. doi: 10.14309/ctg.0000000000000093

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© 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — Diagnostic efficacy of blood Sox10 promoter methylation in IND. (a) ROC curve of the Sox10 promoter methylation level in the diagnosis of HD. (b) ROC curve of the Sox10 promoter methylation level in the diagnosis of IND. The AUC of Sox10 methylation in the diagnosis of IND was 0.94 (95% CI, 0.874–1.000, P = 0.000). At the cutoff value of 85%, the sensitivity is 90.6%, the specificity is 95.0%, the NPV is 90.99%, and PPV is 94.77%. (c) ROC curve of the Sox10 promoter methylation level in the differentiation of IND from HD. The optimal cutoff value of 65% was instructive for IND, with a sensitivity of 56.3%, a specificity of 100%, and a PPV of 100%. Although both sensitivity and accuracy were not satisfactory, the 100% specificity and PPV indicated that when blood Sox10 promoter methylation was lower than 65%, IND was more likely than HD. CI, confidence interval; HD, Hirschsprung disease; IND, intestinal neuronal dysplasia; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.