Table 1.

Different Prostaglandin Receptors and Their Potencies for a Specific Type

Name of Related Prostaglandin	The Potency of Related Prostaglandin to Activate the Related Receptor	G Protein Linkage	Signaling Pathway
Prostaglandin DP1 receptor	PGD2≫PGE2>PGF2α>PGI2=TXA2	Gs alpha subunit	Activates AC, increases cAMP, raises Ca2+
Prostaglandin DP2 receptor	PGD2≫PGF2α=PGE2>PGI2=TXA2	Gi alpha subunit	Inhibits AC to depress cAMP levels
Prostaglandin EP1 receptor	PGE2>PGF2α=PGI2>PGD2=TXA2	Gq alpha subunit	Stimulates PLC, IP3, PKC, ERK, p38 Mpk, and CREB
Prostaglandin EP2 receptor	PGE2>PGF2α=PGI2>PGD2=TXA2	Gs alpha subunit	Stimulates AC, raises cAMP, stimulates beta-catenin and Glycogen synthase kinase 3
Prostaglandin EP3 receptor	PGE2>PGF2α,PGI2>PGD2=TXA2	Gi & G12 subunit	Inhibits AC, decreases cAMP, stimulates PLC & IP3, raises Ca2+
Prostaglandin EP4 receptor	PGE2>PGF2α=PGI2>PGD2=TXA2	Gs alpha subunit	Stimulates AC, PKA, PI3K, AKT, ERK, p38 Mpk, & CREB; raises cAMP
Prostaglandin F2α receptor	PGF2α>PGD2>PGE2>PGI2=TXA2	Gq alpha subunit	Stimulates PLC, IP3, & PKC; raises Ca2+
Prostacyclin I2 receptor	PGI2≫PGD2=PGE2=PGF2α>TXA2	Gs alpha subunit	Stimulates AC & PKA; raises cAMP
Thromboxane A2 receptor	TXA=PGH2≫PGD2=PGE2=PGF2α=PGI2	Gq alpha subunit	Stimulates PLC & IP3; raises Ca2+

Note: It can be seen that every prostaglandin has its own receptors. However, one prostaglandin may react with other types of receptors. The difference in subtypes of receptors may account for the different effects of prostaglandins in a different situation. They generally act through G-proteins. The G-proteins may be stimulatory or inhibitory, but prostaglandins usually act through stimulatory G-proteins. Recently for one new receptor for F2a and I2 have been introduced and more research should be done to be included in the table but in the text, some information has been given.