Table 2.
Protective Roles of NSAIDs and COX Inhibitors in Brain Diseases
| Postulated Prostaglandins and Related Therapies | Brain Diseases |
|---|---|
| COX-1 and COX-2 inhibitors | Schizophrenia |
| Depression | |
| Alzheimer’s disease | |
| Parkinson’s disease | |
| Huntington disease | |
| TXA2 inhibitors | Alzheimer’s disease |
| PGA1 inhibitors | Huntington disease |
| PGF2α inhibitors | Addiction |
| Huntington disease | |
| PGE2 inhibitors | Addiction |
| Alzheimer’s disease | |
| Parkinson’s disease | |
| Huntington disease | |
| Amyotrophic lateral sclerosis (ALS) | |
| PGD2 inhibitors | Multiple Sclerosis |
| Parkinson’s disease | |
| PGJ2 inhibitors | Multiple Sclerosis |
| Parkinson’s disease |
Note: Likewise, by application of selective prostaglandins receptor inhibitors also some certain diseases alleviate. Meanwhile, it should be noted that some prostaglandins selectively react with certain receptors in some cases.