Table 1. Baseline characteristics of controls and cases.
| Controls (n=1,879) | Cases (n=832) | p-value | ||
|---|---|---|---|---|
| Age, years | 65.3 ±7.7 | 65.6 ±7.7 | 0.46 | |
| Sex, male | 62.5% (1174) | 62.5% (520) | 0.99 | |
| Body mass index, kg/m2 | 26.3 ±3.5 | 27.3 ±3.8 | <0.001 | |
| Current smoking | 8.4% (157) | 15.4% (127) | <0.001 | |
| Systolic blood pressure, mmHg | 139 ±18 | 144 ±19 | <0.001 | |
| Diastolic blood pressure, mmHg | 84 ±11 | 86 ±12 | <0.001 | |
| Diabetes mellitus | 1.8% (33) | 6.9% (57) | <0.001 | |
| Lipid-lowering drugs | 1.1% (20) | 3.7% (31) | <0.001 | |
| Anti-hypertensive drugs | 17.5% (329) | 42.3% (352) | <0.001 | |
| ApoC-III-apoB, RLU | 10,026 (5,945-16,068) | 11,080 (6,553-17,604) | 0.001 | |
| ApoC-III-Lp(a), RLU | 7,385 (4,756-11,199) | 8,325 (5,280-14,137) | <0.001 | |
| ApoC-III-apoAI, RLU | 6,423 (4,011-9,414) | 6,749 (4,487-9,847) | 0.005 | |
| Total plasma apoC-III, mg/dL | 4.8 (3.5-6.9) | 5.5 (3.8-7.9) | <0.001 | |
| Total cholesterol, mmol/L | 6.3 ±1.2 | 6.5 ±1.2 | <0.001 | |
| LDL cholesterol, mmol/L | 4.1 ±1.0 | 4.3 ±1.0 | <0.001 | |
| HDL cholesterol, mmol/L | 1.4 ±0.4 | 1.3 ±0.4 | <0.001 | |
| Remnant cholesterol, mmol/L | 0.7 (0.5-1.0) | 0.8 (0.6-1.2) | <0.001 | |
| Triglycerides, mmol/L | 1.7 (1.2-2.3) | 2.0 (1.4-2.8) | <0.001 | |
| Apolipoprotein A-I, mg/dL | 162.2 ±28.9 | 154.6 ±29.3 | <0.001 | |
| Apolipoprotein B, mg/dL | 129.1 ±31.2 | 137.6 ±32.7 | <0.001 | |
| Lipoprotein(a), mg/dL | 8.4 (6.4-13.6) | 9.5 (6.9-24.7) | <0.001 | |
apoC-III, apolipoprotein C-III; RLU, relative light units; LDL, low-density lipoprotein; HDL, high-density lipoprotein; apoCIII-apoAI, apoC-III content on apolipoprotein A-I containing lipoproteins; apoCIII-apoB, apoC-III content on apolipoprotein B-100 containing lipoproteins; apoCIII-Lp(a), apoC-III content on apolipoprotein(a).
Continuous variables with a normal distribution are reported as mean ± standard deviation.
Continuous variables with a non-normal distribution are reported as median (interquartile range).
Dichotomous variables are reported as percentage of total cohort (number).
P-values are for student’ s T-test for continuous variables and Χ2 test for dichotomous variables.
Triglycerides, remnant cholesterol and apoC-III parameters were log-transformed before analysis.
RLU = relative light units.