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. 2020 Jan 16;13:525–540. doi: 10.2147/OTT.S224465

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© 2020 Zhu et al.

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Schematic representation of the key CSC signalling pathways Notch, Wnt, and Hedgehog. Some of the current drugs that target these pathways in CSCs are shown.

Abbreviations: NICD, Notch intracellular domain; CBF-1, C-promoter binding factor-1; TCF/LEF, T cell factor/lymphoid enhancer factor; LRP, Low-density lipoprotein-related receptor; GSK-3β, glycogen synthase kinase 3β; APC, adenomatous polyposis coli; CPB, cAMP-response element-binding binding protein; Gli, glioma-associated oncogene.