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Schematic representation of the key CSC signalling pathways TGF-β, JAK/STAT3, and Nf-κB. Some of the current drugs targeting these pathways in CSCs are shown.
Abbreviations: TGF-β, transforming growth factor-β; R-Smad, receptor-regulated Smad; Co-Smad, common Smad; JAK, Janus kinase; STAT, signal transducer and activator of transcription; NF-κB, nuclear factor kappa-B; IκB, inhibitor of NF-κB; IKK, inhibitor of NF-κB kinase.
