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PAN (vitamin B5) and CoA biosynthesis pathway. T. gondii can de novo–synthesize or uptake PAN and subsequently convert it into CoA within the parasite. The bifunctional enzyme for PAN synthesis is shown in blue. FS for the enzymes are color-coded (in circles). BCAT, branched-chain amino acid transaminase; HMT, hydroxymethyltransferase; PPCL, phosphopantetheine-cysteine ligase; PPCD, phosphopantothenoylcysteine decarboxylase; PPAT, pantetheine-phosphate adenylyl transferase.
