Figure 2.
PAS600–IL-1Ra exhibits an extended plasma half-life. A, plasma levels of IL-1Ra in mice administered subcutaneously with 10 mg/kg (579.5 nmol/kg) anakinra or 10 mg/kg (147.1 nmol/kg) PAS600–IL-1Ra. n = 3. B, blood plasma concentrations of PAS600–IL-1Ra after i.p. administration in mice displayed pharmacokinetics according to the Bateman function, revealing fast biodistribution and a terminal elimination half-life τβ1/2 = 11.3 ± 2.3 h. For comparison, a τβ1/2 value of 2 min was reported for unmodified IL-1Ra (25). Data are presented as mean ± S.D.