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. 2019 Dec 9;295(3):868–882. doi: 10.1074/jbc.RA119.010340

Figure 6.

Figure 6.

6-h pretreatment with PAS800–IL-1Ra and anakinra reduce inflammation in MSU-crystal–induced peritonitis. A–C, i.p. fluid concentrations of mouse IL-6 (A), mouse G-CSF (B), and human IL-1Ra (C) 4 h after i.p. MSU crystal instillation, as in Fig. 5. D–F, plasma concentrations of mouse IL-6 (D), mouse G-CSF (E), and human IL-1Ra (F) from the same experiment. G and H, remaining blood pellet was lysed with 0.5% Triton X-100, as in Fig. 5, and assayed for mouse G-CSF (G) and KC (H). Whole blood, diluted 1 part in 5, was cultured for 24 h and then the supernatant was assayed for mouse IL-6 (I), as in Fig. 5. Data are presented as mean ± S.E.; ns, not significant;*, p < 0.05; **, p < 0.01; ***, p < 0.001; and ****, p < 0.0001 (Control/PAS800–IL-1Ra comparison); #, p < 0.05 (Anakinra/PAS800–IL-1Ra comparison) (two-tailed Student's t test).