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In vitro binding of PASylated IL-1Ra and anakinra. Real-time kinetic SPR analysis on a BIAcore 2000 instrument of PAS800–IL-1Ra (A), PAS600–IL-1Ra (B), and anakinra versus IL-1R1 (as Fc chimera) (C) immobilized on a CM3 sensorchip (ΔRU = 180). The signals for various ligand concentrations are depicted as red lines with curve fits according to a 1:1 Langmuir model shown in black. The resulting kinetic and affinity parameters are listed in Table 1.
