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. 2020 Jan 14;9:447. doi: 10.3389/fcimb.2019.00447

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Copyright © 2020 Cesur, Siraj, Uddin, Durmuş and Çakır.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Numbers of candidate drug targets predicted through in silico gene essentiality simulations in host-mimicking medium [i.e., human body fluid (HBF) and sputum-macrophage (SM)] are given in (A). The genes predicted by the HBF simulation are the subsets of SM derived results. Numbers of human non-homologous genes among essential genes are given in (B) while (C–E), respectively, give the results of the prioritization applied to the essential non-homologous genes using druggability, virulence factor, and broad-spectrum analyses. NEG, non-essential gene; EG, essential gene; NHG, non-homologous gene; HG, homologous gene; UDG, undruggable gene; DG, druggable gene; NVG, non-virulence gene; VG, virulence gene; NST, narrow-spectrum target; and BST, broad-spectrum target.