Skip to main content
. 2020 Jan 14;9:447. doi: 10.3389/fcimb.2019.00447

Table 1.

Prioritization of putative drug targets (elucidated via gene essentiality and homology analyses) in terms of druggability, virulence, and broad-spectrum distribution.

Putative drug target list Prioritization of putative drug targets
Locus ID Description Virulence analysis Druggability analysis Broad spectrum analysis
KPN_02230 kdsA + 12 107
KPN_00194 lpxA + 2 107
KPN_00100 lpxC + 6 101
KPN_00236 gmhA + 1 107
KPN_03963 hldD + 2 58
KPN_01284 fabI 27 117
KPN_00478 purE 1 154
KPN_02000 ribC 1 95
KPN_00020 ribF 3 94
KPN_00367 ribH 14 128
KPN_03599 murA 7 200
KPN_04350 murB 2 56
KPN_00095 murC 3 100
KPN_00092 murD 8 59
KPN_00089 murE 3 110
KPN_00090 murF 1 69
KPN_00094 murG 1 78
KPN_04256 murI 3 61
KPN_04135 glmU 5 149
KPN_04352 coaA 3 59
KPN_03974 coaD 5 148
KPN_00141 panB 2 138
KPN_00140 panC 5 130
KPN_00139 panD 2 94
KPN_03979 dfp 2 151
KPN_02812 dapA 1 139
KPN_00039 dapB 2 96
KPN_00179 dapD 5 67
KPN_01096 tmk 1 97
KPN_01074 pyrC 4 59
KPN_03983 pyrE 2 53
KPN_01277 pyrF 3 92
KPN_01228 nadE* 6 78
KPN_03799 asd 3 63
KPN_02202 galU + 208
KPN_00192 lpxD + 74
KPN_02493 ugd + 4 30

Targets predicted by at least two prioritization approaches are given here. The genes that satisfy all three criteria are given at the top of the table. Target candidates from human body fluid simulation (HBF) are the subset of sputum-macrophage (SM) simulation-derived results and they are given in red letters. The number of the bacterial pathogen genomes containing the potential targets and the number of interacting drugs are listed in the table.

*All HBF medium-predicted genes in the table were also predicted to be drug targets via the generic host medium simulation, apart from nadE. The nadE gene was classified as essential by HBF and SM simulations, but it was not predicted by the generic host medium simulation.