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. 2019 Jun 28;77(2):365–378. doi: 10.1007/s00018-019-03186-2

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — a Localization of the studied missense variants in the structure of the ABCG2 protein (based on Jackson et al. [28]). b The seriously damaged R147W, R383C variants and the Q141K, F373C variants—which showed significantly lower expression and activity in our experiments—localize in the so-called connector area in the ABCG2 structure (dark grey), demonstrating a key role of this region in the expression, maturation and activity of the ABCG2 protein. TMHs: transmembrane helixes, NBD: nucleotide-binding domain, ch: connector/elbow helix