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. 2020 Jan 20;9:8. doi: 10.1038/s41377-020-0245-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The imaging depths are (a, e) 30 μm, (b, f) 100 μm, (c, g) 200 μm, and (d, h) 300 μm; the top right half of the images in (c, d) are denoised for a comparison. The depth is color-coded in (a–d). e–h show the maximum intensity projections (left) and linear intensity profiles (right) of the beads marked in (a–d). i SNR as a function of the penetration depth. Image denoising is applied for a comparison at the deeper depth. The scale bars represent 40 μm (a–d) and 5 μm (e–h).