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. 2020 Jan 20;10:727. doi: 10.1038/s41598-019-56878-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoxia promotes OS cell migration via collagen biosynthesis. (A,B) The hypoxia-induced overexpression of PLOD2 and P4HA1 in both POS and HMPOS cells was confirmed by PRM mass spectrometry; (C,D) Confirmation of the hypoxia-induced increase in the expression of PLOD2 and P4HA1 in both cell types, POS and HMPOS, by western blotting; Targeted bands were cropped, and the full-length bands are shown in Supplementary Figs. S9, S10. (E,F) Images of wound-healing assays of POS cells and HMPOS cells treated with 1 μg/ml of the P4HA1 inhibitor DHB for 6 hours under hypoxic conditions; (G) DHB inhibits the migration abilities of both POS and HMPOS cells under hypoxia. Error bars, ±S.E.M. *p < 0.05, **p < 0.001.