Table 1.
Summary of PRM-based quantification of hypoxia-responsive protein targets.
| Accession Number | Gene Name | Pathway Molecular Function | p Value Treatment in LR | Fold Changea | CV (%) | |
|---|---|---|---|---|---|---|
| HH/NH | HP/NP | |||||
| E2R2C3 | GPI | Glycolysis | 9.01E-05 | 1.84 | 1.60 | 7.01 |
| E2RRC9 | PGK1 | Glycolysis | 5.25E-06 | 2.12 | 2.13 | 7.79 |
| E2RT65 | PGAM1 | Glycolysis | 1.28E-05 | 2.30 | 1.91 | 8.86 |
| F1PAM3 | IDH2 | Glycolysis | 1.63E-04 | 2.08 | 2.07 | 6.21 |
| F1PAZ2 | HK2 | Glycolysis | 8.33E-08 | 3.98 | 3.15 | 6.39 |
| F1PBT3 | ALDOA | Glycolysis | 6.70E-07 | 2.69 | 2.73 | 8.29 |
| F1PCH3 | ENO1 | Glycolysis | 4.53E-04 | 1.79 | 1.36 | 4.79 |
| F1PHR2 | PKM | Glycolysis | 3.81E-05 | 1.50 | 1.42 | 3.15 |
| F1PTZ9 | GAPDH | Glycolysis | 8.58E-06 | 2.12 | 1.78 | 2.81 |
| F1PVW0 | LDHA | Glycolysis | 2.97E-06 | 2.08 | 1.99 | 4.17 |
| F1Q3S9 | PFKL | Glycolysis | 1.67E-06 | 2.38 | 1.89 | 13.85 |
| P54714 | TPI1 | Glycolysis | 2.10E-05 | 2.17 | 1.94 | 1.57 |
| E2RLQ6 | PGLS | PPP | 2.00E-05 | 1.69 | 1.47 | 7.77 |
| F1PE28 | TKT | PPP | 5.80E-02 | 1.45 | 1.16 | 6.88 |
| E2RLA2 | P4HA1 | Collagen Biosynthesis | 3.60E-06 | 1.98 | 1.96 | 8.63 |
| F1P9Z8 | PLOD1 | Collagen Biosynthesis | 4.03E-06 | 2.15 | 1.65 | 8.49 |
| F1PZL5 | PLOD2 | Collagen Biosynthesis | 5.73E-06 | 3.16 | 2.60 | 12.55 |
| J9NZK5 | LOX | Collagen Biosynthesis | 6.90E-05 | 2.22 | 1.86 | 16.01 |
| E2QYF3 | AFG3L2 | Oxidative Stress | 8.98E-02 | 0.80 | 0.99 | 5.95 |
| E2R7L1 | PDIA4 | Oxidative Stress | 5.44E-01 | 1.05 | 1.04 | 4.79 |
| E2RHG2 | PRDX1 | Oxidative Stress | 3.05E-01 | 1.12 | 1.01 | 1.27 |
| E2RNL3 | PRDX4 | Oxidative Stress | 8.25E-04 | 1.48 | 1.30 | 3.04 |
| E2RRD4 | PRDX3 | Oxidative Stress | 2.15E-01 | 1.15 | 1.15 | 3.12 |
| F1PC59 | PRDX6 | Oxidative Stress | 6.74E-01 | 1.09 | 0.99 | 2.98 |
| F1PCG4 | PRDX2 | Oxidative Stress | 8.67E-01 | 0.82 | 1.04 | 7.33 |
| F1PEN6 | TFRC | Oxidative Stress | 9.36E-01 | 1.87 | 1.75 | 18.49 |
| F1PY21 | GSR | Oxidative Stress | 9.79E-01 | 0.70 | 0.71 | 6.60 |
| J9P4L2 | ERP29 | Oxidative Stress | 1.16E-01 | 1.18 | 1.19 | 3.28 |
| J9P813 | SIIGMAR1 | Oxidative Stress | 2.12E-01 | 1.14 | 1.32 | 7.09 |
| E2RNW5 | ERO1L |
Oxidative Stress Immune Editing |
6.90E-06 | 2.98 | 1.99 | 8.25 |
| F1PX14 | EPHA2 | Immune Editing | 3.91E-03 | 1.83 | 1.47 | 5.90 |
| F1P7M0 | NPEPPS | Immune Editing | 5.04E-04 | 1.41 | 1.36 | 6.39 |
| F1PZ54 | HIF1A | Transcriptional Factor | 1.70E-02 | 1.63 | 1.23 | 6.64 |
| O18840 | ACTB | House Keeping | 9.84E-01 | 1.08 | 0.94 | 1.81 |
aHH, HMPOS cells cultured under hypoxic conditions; NH, HMPOS cells cultered under normoxic conditions; HP, POS cells cultured under hypoxic conditions; NP, POS cells cultured under normoxic conditions.