Skip to main content
. 2020 Jan 20;10:702. doi: 10.1038/s41598-020-57627-1

Table 1.

Clinicopathologic and phenotypic data.

Case N. Age Menopause FIGO TMN Size cm. Mitosis/10HPF Necrosis MHC Class I MHC Dynamics Desmin B7H3 Axl IDO Total cells/sq mm Segmented/total DAPI Predominant T cell phenotype
1 39 No IVB pT3aNxM1 6 20 Present +++ induced + + het ++ pos 900 31% Tex-chronic
2 63 Yes IVB pT1bNxM1 16 11 Present +++ constitutive + + ± pos weak 1248 23% Tex-acute
3 34 No N/A N/A 2 9 Absent + induced +++ + het ++ pos 517 15% Deserted
4 36 No IB pT1bN0Mx 11 50 Present ± constitutive ± +++ ++ pos 210 5% Deserted
5 55 Yes IIIB pT3bNxMx 20 18 Absent + induced neg +++ ++ het pos 2567 77% Tex-acute
6 61 Yes IB pT1bNxMx 12 25 Focal + constitutive +++ + het + het pos 474 8% Deserted
7 44 No IVB pT1bNxM1 14 40 Present + constitutive neg ± pos 363 6% Tex-acute
8 40 No IIIB pT3bN0Mx 4 30 Present ± constitutive +++ +het + pos 481 8% Deserted
9 47 No IB pT1bN0Mx 9 35 Focal +++ constitutive + + het neg pos weak 593 14% Deserted
10 62 Yes IB pT1bN0Mx 8 25 Focal +++ induced +++ +/− het + pos weak 1780 38% Tex-acute
11 61 Yes IIB pT2bNxMx 13 25 Focal +++ constitutive neg + + pos 1644 44% Deserted
12 49 No IB pT1bNxMx 11 25 Focal + focal induced neg +++ ± neg 2890 54% Deserted
13 59 Yes IB pT1bNxMx 7 13 Focal ++ het induced neg +++ ++ pos weak 3533 93% Tex-acute
14 35 No IB pT1bNxMx 11 50 Absent + het induced ++ + ++ pos 2756 33% Tex-mixed
15 57 Yes IIIB pT3bN0Mx 7 20 Present + constitutive ++ ++ het neg neg 72 2% Deserted
16 49 No IIIC pT3bN1Mx 14 25 Present +++ induced neg − + neg 1631 33% Tex-chronic
17 60 Yes IB pT1bN0Mx 19 11 Focal + induced neg − ++ pos 984 50% Tex-mixed
18 71 Yes IB pT1bN0Mx 9 35 Focal + constitutive + − ++ pos 645 13% Tex-mixed
19 51 Yes IIIC pT3bN1Mx 19 60 Present +++ constitutive + +/− het ++het neg 1296 27% Tex-chronic
20 69 Yes IB pT1bNxMx 10 40 Present ± induced ++ − ++ pos het 666 21% Deserted
21 34 No IB pT1bN0Mx 3 10 Absent ++ het constitutive +++ − ++ pos 502 10% Deserted

NOTE: Abbreviations: FIGO: International Federation of Gynecology and Obstetrics staging system; TMN: standard for classifying the extent of spread of cancer; HPF: high power fields; het: heterogeneous; Total cells/sq mm: total number of cells in the core, based on DAPI staining; Tex: T cell exhausted. The predominant T cell phenotype was defined based on PD1 vs TCF7 expression: High PD1 – low/absent TCF7: acute exhaustion. Low PD1 – TCF7 present: chronic exhaustion. (See supplementary data).