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. 2020 Jan 14;13:292. doi: 10.3389/fnbeh.2019.00292

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Copyright © 2020 de Guglielmo, Kallupi, Sedighim, Newman and George.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Escalation of oxycodone intake in heterogeneous stock (HS) rats. **p < 0.01, ***p < 0.001, vs. day 1. (B) Escalation of oxycodone intake in male (blue) and female (salmon) HS rats. **p < 0.01, ***p < 0.001, vs. day 1.