Table 1.

Comparison of selected feeding technologies for mini- and microbioreactor devices

Technology	Realized in			Key features	Limitations
	Shake flask	MTP	Micro-STR
Diffusive release from polymer matrix	[13, 34]a	[34, 39]a	–	Ease of use	Relatively slow rates, constant feed only
Diffusive release from reservoir via membrane	[1, 31, 32]	–	–	Good flexibility	Constant feed only, high characterization effort
Enzymatic digestion of non-metabolizable polymer	[17]	[6, 16, 17, 30, 36]	–	Ease of use	Rate control difficult, narrow operating window
Dosing via liquid handling robot	–	[10]a	[33]a	High flexibility	Intermittent feed only, high invest
Dosing via pumps	[14]a	[2, 8]a	[9]	High flexibility	High complexity, investment and operating costs

^aIntegrated system solution commercialized