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. 2019 Dec 6;72(1):109–118. doi: 10.1007/s00251-019-01134-9

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — CDR3 length analysis. The distribution of CDR3α (n = 2008) and CDR3β (n = 5811) lengths are different (KS test, P < 0.0001). The left-shifted CDR3α distribution in relative to the CDR3β suggests a significantly shorter CDR3 in the TCR α chain (a). The similar distribution of entire CDR3β length (b) and the non-VJ region is observed in ID (n = 506) and SD responses (n = 5305) (c). The CDR3β length comparison between naive T cells (n = 3823) and non-naive population reviews significantly longer in the latter (KS test, P < 0.005) (d). The violin plots of non A2-restricted CDR3β (n = 2535) with the mean CDR3β length labels show a negative correlation between the length of epitope and CDR3β (spearman correlation, r = − 0.14). The paired comparison between CDR3β length at 8- to 10-amino acid epitopes with the 11-amino acid long confirms the significantly shorter CDR3β in the longer epitope (Mann–Whitney U test, all P < 0.0001) (e)