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. 2020 Jan 14;10:1323. doi: 10.3389/fgene.2019.01323

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Copyright © 2020 Li, Lu, Ma, Zhao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signature-based risk score is a promising marker in the training and validation cohorts. (A) The process of building the signature containing six genes most correlated with overall survival (OS) in the training set. The hazard ratios (HRs), 95% confidence intervals (CIs) calculated by univariate Cox regression, and the coefficients calculated by multivariate Cox regression using LASSO are shown. (B, C) Risk score distribution, survival overview, and heatmap for patients in the TCGA (B) and ICGC (C) datasets assigned to high- and low-risk groups based on the risk score.