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. 2020 Jan 14;10:1532. doi: 10.3389/fphar.2019.01532

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Copyright © 2020 Ben Shimon, Shavit-Stein, Altman, Pick and Maggio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Minimal traumatic brain injury (mTBI) lowers the threshold of seizure in the pilocarpine mouse model of status epilepicus. (A) Timeline of the experimental procedure. (B) mTBI increased seizure severity upon treatment with a subthreshold low dose concentration of pilocarpine (n = 15 mice/group) while (C) no effect was detected when mTBI and high dose of pilocarpine were combined (n = 22-23 mice/group). While mTBI did not affect mortality in a setting of subthreshold low dose concentration of pilocarpine (D), a higher mortality rate (E) was detected when mTBI was combined with a high dose concentration. Data is presented as mean ± SEM, ∗ p ≤ 0.05, ∗∗ p ≤ 0.01.