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Thrombin and proinflammatory markers expression correlate with seizure severity. Thrombin activity (A) as well as Factor X mRNA expression (B) were increased in animals that underwent a combined treatment with minimal traumatic brain injury (mTBI) and pilocarpine. The mRNA expression of proinflammatory markers such as TNFa (C) and IL1b (D) were also enhanced in the same group (n = 5-19 mice/group). Data is presented as mean ± SEM, ∗ p ≤ 0.05.
