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. 2020 Jan 20;10:732. doi: 10.1038/s41598-019-57292-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of anxiety-related behavior in mice treated with 5 μg MIA-690 or 5 μg MR-409 (n = 18 for each group of treatment). Compared to the vehicle, MIA-690 (2–4 wk) and MR-409 (4 wk) decreased anxiety-like behavior in elevated plus maze test. MIA-690 was more effective than MR-409 (2–4 wk). Data are expressed as means ± S.E.M. and analyzed by analysis of variance (ANOVA) followed by Bonferroni post-hoc test *p < 0.05, ***p < 0.005 vs. control; ^#p < 0.05, ^##p < 0.005 and ^###p < 0.001 vs. MR-409 treated mice.