Table 1.
Clinical characteristics of the control, preperimetric glaucoma and OAG groups.
| Variable | Control | Preperimetric Glaucoma | OAG | P value | ||
|---|---|---|---|---|---|---|
| Mild | Moderate | Severe | ||||
| Number of eyes | 30 | 30 | 35 | 29 | 41 | — |
| Sex (m/f) | 12/18 | 10/20 | 17/18 | 15/14 | 32/9 | 0.002 |
| Age (years) | 68.1 ± 11.8 | 66.3 ± 10.5 | 71.3 ± 11.0 | 69.1 ± 13.9 | 71.4 ± 8.7 | 0.070 |
| BCVA (logMAR) | 0.05 ± 0.08 | 0.05 ± 0.08 | 0.03 ± 0.06 | 0.06 ± 0.09 | 0.16 ± 0.22 | <0.001 |
| Refraction (diopter) | −1.25 ± 2.06 | −2.26 ± 2.22 | −2.07 ± 2.14 | −2.21 ± 1.96 | −2.38 ± 2.26 | 0.342 |
| Axial Length (mm) | 24.29 ± 0.92 | 25.11 ± 1.22 | 24.43 ± 0.98 | 24.86 ± 1.74 | 25.01 ± 1.55 | 0.610 |
| IOP (mmHg) | 15.2 ± 2.9 | 13.8 ± 2.4 | 13.7 ± 3.1 | 12.7 ± 4.4 | 12.5 ± 3.4 | 0.014 |
| MD (dB) | 0.49 ± 0.58 | −0.49 ± 0.78 | −3.20 ± 1.41 | −9.10 ± 1.54 | −18.97 ± 5.26 | <0.001 |
| cpRNFLT(µm) | 96.32 ± 10.85 | 81.43 ± 7.92 | 73.17 ± 9.63 | 64.41 ± 9.32 | 62.66 ± 4.75 | <0.001 |
| mGCIPLT (µm) | 79.83 ± 8.57 | 73.03 ± 9.67 | 67.47 ± 9.60 | 62.38 ± 8.63 | 60.70 ± 10.99 | <0.001 |
| SBP (mmHg) | 131.2 ± 20.9 | 133.0 ± 20.0 | 128.1 ± 16.2 | 131.1 ± 18.1 | 131.3 ± 22.3 | 0.842 |
| DBP (mmHg) | 75.9 ± 12.2 | 78.8 ± 10.9 | 73.9 ± 11.6 | 77.5 ± 12.1 | 75.9 ± 13.4 | 0.401 |
| MAP (mmHg) | 94.4 ± 14.6 | 96.9 ± 13.1 | 91.9 ± 12.6 | 95.4 ± 13.7 | 94.4 ± 16.0 | 0.589 |
| MOPP (mmHg) | 47.7 ± 9.2 | 51.2 ± 8.6 | 47.6 ± 8.6 | 50.9 ± 8.9 | 50.5 ± 10.7 | 0.206 |
| HR (bpm) | 72.3 ± 10.8 | 73.3 ± 10.9 | 72.6 ± 8.8 | 70.0 ± 8.6 | 72.5 ± 10.9 | 0.350 |
| Choroidal MBR | 8.28 ± 2.24 | 8.71 ± 2.95 | 9.35 ± 2.96 | 9.29 ± 2.83 | 7.76 ± 2.24 | 0.048 |
| ONH MBR- vessel (AU) | 40.44 ± 7.63 | 38.82 ± 9.61 | 36.05 ± 7.56 | 30.85 ± 9.36 | 27.02 ± 7.48 | <0.001 |
| ONH MBR- tissue (AU) | 10.89 ± 2.47 | 10.63 ± 2.10 | 10.19 ± 1.69 | 9.37 ± 1.89 | 6.95 ± 1.61 | <0.001 |
| ONH MBR- overall (AU) | 21.01 ± 4.09 | 19.65 ± 4.95 | 17.65 ± 3.82 | 15.20 ± 3.88 | 12.23 ± 3.35 | <0.001 |
| Trabeculectomy (n/%) | 0/0.0 | 0/0.0 | 4/11.4 | 8/27.6 | 30/73.1 | <0.001 |
| Trabeculotomy (n/%) | 0/0.0 | 0/0.0 | 0/0.0 | 2/6.9 | 2/4.9 | 0.236 |
| Pseudophakia (n/%) | 8/26.7 | 11/36.7 | 17/48.6 | 14/48.3 | 27/65.9 | 0.016 |
| Diabetes mellitus disease (n/%) | 11/36.7 | 10/33.3 | 10/28.6 | 10/34.5 | 22/53.7 | 0.052 |
| Hypertension disease (n/%) | 12/40.0 | 12/40.0 | 14/40.0 | 10/34.5 | 16/39.0 | 0.991 |
| Intracranial disease (n/%) | 4/13.3 | 0/0.0 | 0/0.0 | 2/6.9 | 5/6.1 | 0.040 |
| Antithrombotic medication (n/%) | 1/3.3 | 7/23.3 | 1/2.9 | 2/6.9 | 9/22.0 | 0.011 |
| glaucoma medication (n/%) | 0/0.0 | 13/43.3 | 31/88.6 | 20/69.0 | 33/80.4 | <0.001 |
OAG: open angle glaucoma, BCVA: best-corrected visual acuity, logMAR: logarithm of the minimum angle of resolution,
IOP: intraocular pressure, MD: mean deviation, cpRNFLT: circumpapillary retinal nerve fiber layer thickness,
mGCIPLT: macular ganglion cell inner plex layer thickness, SBP: systemic blood pressure, DBP: diastolic blood pressure,
MAP: mean arterial blood pressure, MOPP: mean ocular perfusion pressure, HR: heart rate, ONH: optic nerve head, MBR: mean blur rate.
AU: arbitrary units.