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. 2020 Jan 20;10:709. doi: 10.1038/s41598-019-57388-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue-specific syntaxin-3 conditional KO mice do not decrease in basal synaptic transmission. Schaffer collateral axonal fibers were administered two successive stimulations from 10 to 150 µA and the resulting local fEPSPs from apical dendrites of CA1 pyramidal neurons were recorded. (a,b) Averaged traces of dendritic fEPSPs from syntaxin-3 flox/flox (control) (a) and syntaxin-3 flox/flox; CaMK2a-Cre (cKO) (b). (C and D) fEPSP amplitudes (c) or slopes (d) were plotted against presynaptic fiber volley amplitudes. (E and F) Paired-pulse ratios of amplitudes (e) or slopes (f) were plotted against presynaptic fiber volley amplitudes. Error bars indicate SEM (animal: n = 16 for control and n = 11 for syntaxin-3 cKO groups).