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. 2020 Jan 20;10:709. doi: 10.1038/s41598-019-57388-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue-specific syntaxin-3 KO mice exhibit normal learning and memory in Morris water maze task. (a) Protocol outline used for Morris water maze test. A total of 4 trials were conducted on each animal per day, and entry points to the pool were randomized. The distance and latency to find the platform was measured for a visible platform on days 1 to 3 and a hidden platform on days 4 to 12. The hidden platform location was modified from the visible platform. During the probe test, the platform was removed from the pool and percentage of time spent in the quadrant of the previous location of the platform was calculated from a total recording time of 60 sec. (b) The training acquisition curves of finding the visible (days 1 to 3) or hidden (days 4 to 15) platform. Average latency of finding the platform during the 4 daily trials. (c) On days 6, 9 and 12, time spent in the quadrant where the platform was previously located was measured. Error bars indicate s.e.m. (animal n = 5 for both groups). Both control and cKO groups spent more time in the trained quadrant than the random 25%. N.S. indicates nonsignificant (p > 0.05) between the two groups; mixed ANOVA test.