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. 2020 Jan 20;10:631. doi: 10.1038/s41598-020-57462-4

Figure 3.

Figure 3

Dopamine-induced calcium transients in OB astrocytes in synaptic isolation. (A) Example of multiple applications of DA (100 µM) with a 10-min interval. (B) Calcium transients were not affected in presence of GABAergic, glutamatergic und purinergic antagonists (Blockermix contains: NBQX 10 µM, D-APV 50 µM, gabazine 10 µM, CGP55845 10 µM, MPEP 2 µM, MRS2179 50 µM, ZM241385 0.5 µM, TTX 1 µM). (C) Normalized averaged amplitudes (light grey, +/−SEM) and area (dark grey, +/−SEM) of calcium responses under control conditions and after application of Blockermix (BM). Results of BM are additionally compared to rundown (RD) experiment as depicted in (A) (error bars: SEM). *P < 0.05, **P < 0.01, ***P < 0.005.