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. 2020 Jan 20;10:631. doi: 10.1038/s41598-020-57462-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of DA receptor antagonists on dopamine-induced calcium signaling in OB astrocytes. (A) Calcium transients evoked by DA (30 s, 100 µM) where reduced in amplitude and integral in the presence of D1-class antagonist SCH23390 (50 µM). (B) Normalized averaged amplitude and area of calcium responses in presence of SCH23390. (C) Calcium transients where reduced in the presence of D2-class antagonist sulpiride (50 µM). (D) Normalized averaged amplitude and area of calcium responses in presence of sulpiride. (E) Effect of both SCH23390 and sulpiride on dopamine-evoked calcium responses. (F) Normalized averaged amplitude and area (+/−SEM) of calcium responses in the presence of both antagonists. *P < 0.05, **P < 0.01, ***P < 0.005.