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. 2020 Jan 20;10:641. doi: 10.1038/s41598-020-57496-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loco-regional recurrence-free survival (LRFS) according to p-S6K1 expression status in patients with or without radiotherapy. Kaplan-Meier estimates of LRFS among patients treated with (a) and without (b) radiotherapy. Patients with positive p-S6K1 expression showed significantly worse LRFS compared to those with negative p-S6K1 expression when treated with radiotherapy (*p = 0.015). In contrast, no difference in LRFS based on p-S6K1 expression status was seen in patients who did not receive radiotherapy (*p = 0.702). *Kaplan-Meier survival estimate compared by a log-rank test.