Table 1.
List of assigned statistically significant metabolites of the serum, heart, liver, brain and kidney between the CUMS group and the control group.
| Metabolites | HMDB | VIP | p-Value | Fold Change |
|---|---|---|---|---|
| Serum | ||||
| Oleamide | HMDB0002117 | 1.75 | 2.49E-04 | 5.57E-01 |
| Linoleic acid | HMDB0000673 | 1.63 | 1.04E-03 | 6.84E-01 |
| Urea | HMDB0000294 | 1.46 | 4.96E-03 | 1.97E+00 |
| L-Glutamic acid | HMDB0000148 | 1.44 | 6.16E-03 | 4.69E+00 |
| Palmitic acid | HMDB0000220 | 1.39 | 8.61E-03 | 7.17E-01 |
| D-Lyxose | HMDB0003402 | 1.38 | 9.49E-03 | 3.93E-01 |
| L-Methionine | HMDB0000696 | 1.33 | 1.29E-02 | 4.02E+00 |
| L-Alanine | HMDB0000161 | 1.33 | 1.36E-02 | 5.25E+00 |
| Myristic acid | HMDB0000806 | 1.31 | 1.46E-02 | 7.35E-01 |
| L-Phenylalanine | HMDB0000159 | 1.26 | 2.05E-02 | 2.40E+00 |
| Heart | ||||
| Phenol | HMDB0000228 | 1.59 | 4.75E-07 | 5.90E+00 |
| L-Valine | HMDB0000883 | 1.56 | 1.68E-06 | 6.58E+00 |
| Urea | HMDB0000294 | 1.44 | 6.13E-05 | 2.21E+00 |
| Glycine | HMDB0000123 | 1.29 | 9.72E-04 | 2.10E-01 |
| L-Alanine | HMDB0000161 | 1.27 | 1.14E-03 | 5.13E+00 |
| L-Threonine | HMDB0000167 | 1.22 | 2.28E-03 | 4.41E+00 |
| D-Lactic acid | HMDB0001311 | 1.20 | 3.04E-03 | 1.93E+00 |
| Stearic acid | HMDB0000827 | 1.12 | 6.90E-03 | 3.98E-01 |
| Propionic acid | HMDB0000237 | 1.09 | 8.51E-03 | 1.75E-01 |
| Uracil | HMDB0000300 | 1.06 | 1.12E-02 | 3.40E-01 |
| Liver | ||||
| Oxalic acid | HMDB0002329 | 1.87 | 2.31E-04 | 3.18E+00 |
| Uracil | HMDB0000300 | 1.80 | 5.40E-04 | 2.72E-01 |
| Stearic acid | HMDB0000827 | 1.79 | 5.74E-04 | 3.88E-01 |
| Palmitoleic acid | HMDB0003229 | 1.60 | 3.69E-03 | 3.51E-01 |
| Palmitic acid | HMDB0000220 | 1.44 | 1.16E-02 | 5.24E-01 |
| L-Threonine | HMDB0000167 | 1.35 | 1.98E-02 | 2.48E+00 |
| D-Glucose | HMDB0000122 | 1.31 | 2.46E-02 | 1.84E+00 |
| D-Lactic acid | HMDB0001311 | 1.29 | 2.67E-02 | 1.64E+00 |
| Linoleic acid | HMDB0000673 | 1.23 | 3.66E-02 | 4.79E-01 |
| Brain | ||||
| Cholesterol | HMDB0000067 | 1.38 | 1.85E-06 | 1.50E-01 |
| D-Lactic acid | HMDB0001311 | 1.28 | 5.91E-05 | 5.49E+00 |
| Carbamic acid | HMDB0003551 | 1.27 | 6.67E-05 | 7.97E+00 |
| Stearic acid | HMDB0000827 | 1.18 | 5.22E-04 | 1.11E-01 |
| Kidney | ||||
| L-Serine | HMDB0000187 | 1.57 | 1.18E-04 | 2.74E-01 |
| D-Glucose | HMDB0000122 | 1.39 | 1.47E-03 | 3.32E+00 |
| L-Isoleucine | HMDB0000172 | 1.38 | 1.63E-03 | 2.74E-01 |
| L-Norleucine | HMDB0001645 | 1.37 | 1.97E-03 | 1.34E-01 |
| Uracil | HMDB0000300 | 1.28 | 4.64E-03 | 1.30E-01 |
| 3-Hydroxybutyric acid | HMDB0000357 | 1.17 | 1.25E-02 | 2.73E+00 |
| D-Lactic acid | HMDB0001311 | 1.14 | 1.55E-02 | 1.90E+00 |
Abbreviations: HMDB: the Human Metabolome Database, Fold change: CUMS/Control, VIP: variable influence on projection.