Table 2.
Results from pathway analysis by MetaboAnalyst 4.0.
| Pathway name | Total | Expected | Hits | Raw p | Holm adjust | FDR | Impact |
|---|---|---|---|---|---|---|---|
| Serum | |||||||
| Alanine, aspartate and glutamate metabolism | 24 | 1.71E-01 | 2 | 1.16E-02 | 0.93018 | 3.74E-01 | 2.59E-01 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 4 | 2.85E-02 | 1 | 2.83E-02 | 1 | 3.74E-01 | 5.00E-01 |
| D-Glutamine and D-glutamate metabolism | 5 | 3.57E-02 | 1 | 3.52E-02 | 1 | 3.74E-01 | 1.00E+00 |
| Linoleic acid metabolism* | 5 | 3.57E-02 | 1 | 3.52E-02 | 1 | 3.74E-01 | 1.00E+00 |
| Arginine and proline metabolism | 44 | 3.14E-01 | 2 | 3.69E-02 | 1 | 3.74E-01 | 9.35E-02 |
| Heart | |||||||
| Glycine, serine and threonine metabolism | 32 | 2.28E-01 | 2 | 2.03E-02 | 1 | 5.47E-01 | 2.92E-01 |
| Liver | |||||||
| Linoleic acid metabolism* | 5 | 3.21E-02 | 1 | 3.17E-02 | 1 | 8.57E-01 | 1.00E+00 |
| Brain | |||||||
| Pyruvate metabolism | 22 | 6.28E-02 | 1 | 6.14E-02 | 1 | 1.00E+00 | 9.74E-02 |
| Kidney | |||||||
| Aminoacyl-tRNA biosynthesis | 67 | 3.35E-01 | 2 | 4.04E-02 | 1 | 8.07E-01 | 1.38E-01 |
| Methane metabolism | 9 | 4.49E-02 | 1 | 4.42E-02 | 1 | 8.07E-01 | 4.00E-01 |
Abbreviations: FDR: false discovery rate.