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. 2020 Jan 20;10:643. doi: 10.1038/s41598-019-57218-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

RNA expressions of gene signatures associated with therapeutic response and improved outcome to anti-PD-1. (a) The expression of M1 signature is significantly higher in DCB group compared to NDB group (t-test, P = 4.95e⁻⁴). (b) Patients with high M1 signature have significantly prolonged progression-free survival than those with low M1 signature (log-rank, P = 7.84 e⁻⁴). (c) Patients with high M1 signature have similar overall survival than those with low M1 signature (log-rank, P = 0.348). (d) The expression of peripheral T cell signature was significantly higher in DCB group compared to NDB group (t-test, P = 1.08e⁻⁴). (e) High peripheral T cell signature was associated with significantly prolonged progression-free survival (log-rank, P = 8.29e⁻³). (f) Patients with high peripheral T cell signature have similar overall survival than those with low signature (log-rank, P = 0.695).