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. 2019 Dec 24;23(1):100794. doi: 10.1016/j.isci.2019.100794

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Evidence for D1-D2 Heteromer Existence in Different Species

(A–F) Dopamine D1-D2 heteromers were revealed by PLA using specific D1 and D2 receptor antibodies directly conjugated to the Minus and Plus probes. PLA signal (red spots) was observed in striatal slices from mouse (A), rat (B), monkey (C and D), and humans (E). Quantification of the percentage of neurons (nuclei stained by DAPI) showing PLA signals in the dorsal striatum (caudate nucleus, CPu) and the ventral striatum (nucleus accumbens, NAc) in different species. Analyses included male only and showed regional and species differences (F). Two-way ANOVA test (p < 0.0001). Scale bars, 10 μm.