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. 2019 Dec 24;23(1):100794. doi: 10.1016/j.isci.2019.100794

Figure 4.

Figure 4

Molecular Mechanisms Involved in the Effects of Chronic THC and CBD: CaMKIIα and AMPA-GluA1

(A–D) Monkeys (N = 3 per group) were treated chronically with vehicle, THC, or THC + CBD. Homogenates from the NAc (A) or CPu (B) were subjected to western blot with antibodies for phospho-CaMKIIα (pCaMKIIα, A and B) or phosphoSerine845-GluA1 (p845, C and D). GAPDH was used as loading control. Representative images (top) and quantification of the density (bottom) are shown. Data are mean ± SD. One-way ANOVA followed by Bonferroni correction was used to compare statistical differences. (**p < 0.01; ***p < 0.001).