Table 1. The in silico analysis of the observed nonsynonymous SNPs in PBP2A using the commonly available bioinformatics tools to shows their potential effects and their potential post-translation interactions.

SNP	SIFT		Poly-Phen-2		PROVEAN		SNAP2		ConSurf		Phosphorylation Glycation Ubiquitylation	FTsite
	Score	Prediction	Score	Prediction	Score	Prediction	Score	Prediction	Score	Prediction	Prediction	Prediction
N57T	0.55	Tolerated	0.081	Benign	1.403	Neutral	−63	Neutral	5	Average, buried	No	No
N115Y	0.08	Tolerated	0.789	Possibly damaging	−2.051	Neutral	39	Effect	1	Variable, exposed	No	No
D120N	0.07	Tolerated	0.059	Benign	−1.464	Neutral	14	Effect	1	Variable, exposed	No	No
D139N	0.00	Affect function	0.003	Benign	−0.160	Neutral	−10	Neutral	1	Variable, exposed	No	No
G152V	0.00	Affect function	1.000	Probably damaging	−8.937	Deleterious	17	Effect	9	Conserved, exposed, functional	No	Yes, binding site 2
E189K	1.00	Tolerated	0.001	Benign	0.680	Neutral	11	Effect	3	Variable, buried	No	No
F211V	0.34	Tolerated	1.000	Probably damaging	−5.970	Deleterious	−21	Neutral	8	Conserved, buried	No	No