Figure 5. Nup93 plays a critical role in tumor propagation in vitro and in vivo.

(A, B) NUP93 KD BCCs (A) proliferate less than control cells (B). C2-C3-C5-C6 represents different NUP93 KD clones. t test with P < 0.001 (***), N = 3 independent FACS analyses. (C) NUP93 KD BCCs are more apoptotic than control cells. t test with P < 0.001 (***), N = 3 independent FACS analyses. (D, E) NUP93 KD reduces the ability of BCCs to form tumors in vivo. Data refer to the “D10 dox” group. Identical results were obtained for the “D0 dox” group. t test with P < 0.001 (***), N = 7 animals per group, data normalized to ctrl. (E) Representative FACS plot of a tumor from the “D10 dox” group showing the ratio between ctrl and 93 KD cells.

Source data are available for this figure.