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. 2019 Dec 27;23(1):100807. doi: 10.1016/j.isci.2019.100807

Figure 6.

Figure 6

IFN-DC Participates in the Anti-Psoriasis Process of Spermidine

(A) Schematic diagram for IMQ application and depletion of neutrophils alone (Anti-Ly6G) or monocytes plus neutrophils (Anti-Gr1) in mice.

(B) Phenotypic presentation.

(C) Increase in redness score and scaling score (n = 5).

(D and E) (D) H&E staining of skin lesions of representative mice on day 5. Magnification 100× (scale bars represent 100 μm). (E, upper) Skin epidermal and epidermal plus dermal thickness, and (lower) ear epidermal and epidermal plus dermal thickness on day 5 (n = 4).

(F) The protein levels of IL-23, TNF-α, IL-6, and IL-17A in serum (n = 5). Each dot represents a mouse.

All data are representative of three independent experiments and shown as mean ± SEM. P values were determined by an unpaired t test or two-way ANOVA. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. not significant.