Table 2.

Changes in LV diastolic function and aortic stiffness assessed by mitral valve pulse flow and tissue Doppler

Parameter	Day 1	Day 3	Week 1	Week 2	Week 4	Week 8	Overall time effect
MV E vel ( mm/s)
Control	336 ± 15	449 ± 21	542 ± 19	658 ± 20	920 ± 39	1,035 ± 30
Hypoxia	314 ± 22	524 ± 16	541 ± 24	703 ± 26	847 ± 38	868 ± 32*	p = .000
MV A vel (mm/s)
Control	436 ± 17	493 ± 30	475 ± 21	459 ± 17	575 ± 20	646 ± 30
Hypoxia	408 ± 22	596 ± 20	545 ± 20	528 ± 25	619 ± 25	650 ± 35	p = .000
LV LW E’ vel (mm/s)
Control	13.3 ± 1.6	13.6 ± 1.2	16.4 ± 0.6	20.3 ± 1.0	44.3 ± 2.4	52.9 ± 2.8
Hypoxia	9.5 ± 0.7	12.3 ± 0.6	14.4 ± 0.5	26.0 ± 1.7* , a	36.6 ± 2.9	52.6 ± 3.5	p = .000
LV LW A’ vel (mm/s)
Control	18.8 ± 1.9	18.4 ± 1.4	19.9 ± 0.8	19.4 ± 1.3	39.2 ± 2.0	46.4 ± 2.5
Hypoxia	16.7 ± 1.0	18.9 ± 0.7	21.2 ± 0.5	29.8 ± 0.8*	43.4 ± 3.4	65.3 ± 5.0*	p = .000
LV LW E’/A’ vel
Control	0.70 ± 0.02	0.73 ± 0.02	0.83 ± 0.03	1.08 ± 0.06	1.14 ± 0.04	1.16 ± 0.05
Hypoxia	0.58 ± 0.03	0.65 ± 0.03	0.68 ± 0.02*	0.89 ± 0.08	0.85 ± 0.02*	0.82 ± 0.03*	p = .000
AOd‐PWV (m/s)
Control	2.9 ± 0.2	2.4 ± 0.1	2.1 ± 0.1	2.2 ± 0.1	3.6 ± 0.2	3.9 ± 0.2
Hypoxia	12.2 ± 0.3.1*	9.6 ± 1.4*	8.6 ± 2.5*	3.6 ± 0.3*	4.5 ± 0.5	5.4 ± 0.3*	p = .000

AOd‐pulse wave velocity (PWV) at the diaphragm; MV‐mitral valve; LV LW‐left ventricle lateral wall, vel‐peak velocity. All data are presented as mean ± SE. Highlighted variables represent those with differences between prenatal hypoxia‐exposed and control pups at specific ages.

^aNo statistical difference when the effect of litter was incorporated into the analysis.

^* p < .008 for differences between hypoxia exposed and control pups at a given age.