Table 1. Associations of phylum-level compositions and alpha-diversity indices of the gut microbiota with fecal SCFAs after adjusting for sex and age.
| Fecal total SCFAs† |
Fecal acetate† |
Fecal butyrate† |
Fecal propionate† |
||||||
|---|---|---|---|---|---|---|---|---|---|
| β | 95%CI‡ | β | 95%CI‡ | β | 95%CI‡ | β | 95%CI‡ | ||
| Phylum (%) | |||||||||
| Actinobacteria | −7.88 | (−23.30, 7.54) | −7.3 | (−22.81, 8.21) | −9.93 | (−26.44, 6.59) | −4.86 | (−20.92, 11.20) | |
| Bacteroidetes | −2.21 | (−10.70, 6.28) | −2.44 | (−10.84, 5.96) | −8.04 | (−14.99, −1.09)* | 4.48 | (−3.30, 12.27) | |
| Firmicutes | 4.11 | (−3.91, 12.12) | 4.17 | (−3.77, 12.11) | 9.73 | (4.39, 15.07)* | −2.65 | (−10.98, 5.68) | |
| Proteobacteria | −0.20 | (−54.23, 53.84) | 1.42 | (−52.3, 55.14) | 29.64 | (−24.71, 83.98) | −30.03 | (−77.62, 17.55) | |
| Alpha-diversity indices | |||||||||
| F:B ratio | 1.3 | (−2.15, 4.76) | 1.11 | (−1.66, 3.87) | 0.42 | (0.1, 0.75)* | −0.23 | (−0.78, 0.32) | |
| Shannon index | 1.08 | (−0.43, 2.59) | 1.1 | (−0.39, 2.59) | 1.82 | (0.6, 3.05)* | −0.18 | (−1.90, 1.55) | |
| Simpson index | 9.06 | (−5.66, 23.77) | 9.63 | (−4.74, 24.00) | 15.13 | (1.85, 28.41)* | −3.36 | (−19.44, 12.71) | |
| Inverse Simpson index | 0.14 | (−0.06, 0.34) | 0.15 | (−0.05, 0.35) | 0.25 | (0.08, 0.41)* | −0.06 | (−0.28, 0.17) | |
| Chao 1 index | 0.003 | (−0.015, 0.020) | 0.002 | (−0.015, 0.02) | 0.009 | (0.01, 0.027) | −0.002 | (−0.020, 0.015) | |
| Observed OTUs | 0.009 | (−0.011, 0.030) | 0.009 | (−0.011, 0.029) | 0.015 | (0.006, 0.035) | 0.002 | (−0.020, 0.023) | |
| PD whole tree | 0.17 | (−0.23, 0.56) | 0.16 | (−0.23, 0.55) | 0.19 | (0.24, 0.62) | 0.09 | (−0.32, 0.49) | |
CI: confidence interval; F:B: Firmicutes to Bacteroidetes; OTUs: operational taxonomic units; PD: phylogenetic diversity; SCFAs: short-chain fatty acids. †Values were standardized. ‡Linear regression analyses, adjusted for age and sex. *p<0.05.