Table 1.
Clinical Manifestations in patients with selective IgM deficiency
| Patient | Age | Sex | IgM | Clinical Manifestations | |
|---|---|---|---|---|---|
|
| |||||
| Recurrent or Chronic Infections | Allergic & Autoimmune Disease | ||||
| 1 | 35 | F | 33 | Intertrigo and vaginal candidiasis | -- |
| 2 | 45 | M | 35 | Cellulitis, recurrent URI | -- |
| 3 | 65 | F | 40 | Lymphadenitis, sinusitis, Mycobacterium tuberculosis, bronchiectasis obliterans | Hypothyroidism, |
| Sjogren’s Syndrome | |||||
| 4 | 75 | F | 42 | -- | Guillian Barre Syndrome |
| 5 | 42 | F | 56 | HSV | -- |
| 6 | 49 | F | 13 | Recurrent URI, pneumonia, and UTI | Asthma, Sjogren’s Syndrome |
| 7 | 60 | M | 38 | -- | Rheumatoid Arthritis |
| 8 | 32 | F | 37 | Recurrent UTI | Allergic Rhinitis, autoimmune neutropenia, thrombocytopenia |
| 9 | Deceased | M | 61 | -- | ANA 1:160 |
| 10 | 60 | F | 23 | Otitis media, pharyngitis, chronic sinusitis, pneumonias | Hashimoto’s thyroiditis |
| 11 | 57 | M | 39 | Viral meningitis, recurrent URI and pneumonia | -- |
| 12 | 71 | M | 32 | Herpes Zoster with post herpetic neuralgia | Hashimoto’s thyroiditis, ocular myasthenia gravis |
| 13 | 55 | F | 47 | Chronic sinusitis, tooth abscess | Hashimoto’s Thyroiditis, autoimmune pancreatitis, Celiac Disease |
| 14 | 74 | F | 49 | Recurrent URI | -- |
| 15 | 56 | F | 20 | Chronic Sinusitis | Asthma, hypothyroidism |
| 16 | 47 | M | 34 | Recurrent URI, chronic sinusitis | -- |
| 17 | 12 | F | 34 | Asceptic meningitis, Staph and fungal skin infections | Asthma, Allergic Rhinitis |
| 18 | 59 | F | 62 | Necrotizing fasciitis, MRSA abscesses, recurrent URIs, pharyngitis, sinusitis, pneumonia x 2, recurrent UTI | Asthma, hypothyroidism |
| 19 | 90 | F | 25 | -- | Asthma, Allergic Rhinitis, Rheumatoid arthritis |
| 20 | 85 | M | 52 | Bronchitis, pneumonia | -- |
| 21 | 77 | F | 47 | Recurrent pneumonia | -- |
| 22 | 51 | F | 12 | Bronchitis, sinusitis, otitis media | Asthma, Hypothyroidism |
| 23 | 56 | F | 52 | Sinusitis | Allergic Rhinitis |
| 24 | 44 | M | 40 | Bronchitis, pneumonia, MAC infection | Asthma, Allergic Rhinitis |
| 25 | 24 | M | 56 | Sinusitis, pneumonia | ANA 1:180 |
| 26 | 39 | M | 41 | Skin abscesses, cellulitis | -- |
| 27 | 51 | F | 32 | Rec. URI, sinusitis, otitis media, Rec. UTI, vaginal bacterial infections | -- |
| 28 | 74 | M | 45 | Recurrent URI | -- |
| 29 | 42 | F | 44 | -- | Hypothyroidism |
| 30 | 17 | M | 50 | -- | Allergic Rhinitis, alopecia |
| 31 | 40 | M | 43 | Recurrent URI | -- |
| 32 | 65 | F | 35 | Chronic Sinusitis | Asthma, Allergic Rhinitis, Guillan-Barre Syndrome |
| 33 | 60 | F | 10 | HSV, Chronic Fungal sinusitis | Celiac disease |
| 34 | 57 | F | 43 | Recurrent URI | Asthma, Allergic Rhinitis, Hyperthyroidism |
| 35 | 35 | F | 35 | Recurrent URI, chronic sinusitis | Hypothyroidism, Adrenal Insufficiency, Myasthenia Gravis |
| 36 | 72 | M | 39 | Bronchitis, sinusitis, pneumonias | -- |
| 37 | 63 | F | 39 | Chronic bronchitis, chronic fungal sinusitis | Asthma, Allergic Rhinitis |
| 38 | 67 | F | 53 | Recurrent UTI | Allergic Rhinitis |
| 39 | 87 | M | 27 | Pneumonias, MAC infection | -- |
| 40 | 62 | F | 14 | Pneumonias | SLE, cutaneous lupus |
| 41 | 82 | F | 53 | Recurrent UTI | SLE, APS |
| 42 | 56 | F | 24 | Recurrent URI | Allergic Rhinitis |
| 43 | 44 | M | 15 | Periodontal abscesses | Allergic Rhinitis |
| 44 | 73 | F | 21 | -- | Allergic Rhinitis, hypothyroidism, ITP |
| 45 | 60 | M | 52 | Recurrent URI | -- |
| 46 | 72 | F | 4 | Diverticulitis, Recurrent UTI | -- |
| 47 | 57 | M | 34 | Skin Abscesses, Recurrent URI, sinusitis | ANA >1:320 |
| 48 | 79 | F | 64 | Recurrent URI | -- |
| 49 | 50 | M | 46 | Chronic sinusitis | -- |
| 50 | 21 | F | 55 | Recurrent shingles | Hashimoto’s thyroiditis |
| 51 | 59 | F | 50 | Recurrent URI | Asthma, Hashimoto’s thyroiditis |
| 52 | 62 | M | 62 | Bronchiectasis | Allergic Rhinitis, ANA 1:160 |
| 53 | 42 | M | 57 | Chronic bronchitis | -- |
| 54 | 64 | F | 57 | Chronic sinusitis | Asthma, Allergic Rhinitis |
| 55 | 31 | F | 45 | Pneumonia, Recurrent UTI | Asthma, Allergic Rhinitis |
| 56 | 43 | F | 49 | Onychomycosis, Recurrent otitis media, pharyngitis, sinusitis, thrush, and pneumonia , MAI, Bronchiectasis | Asthma, Allergic Rhinitis |
| 57 | 44 | F | 51 | URI, chronic sinusitis, chronic diarrhea, UTI | undifferentiated connective tissue disease |
| 58 | 73 | M | 18 | Pneumonia with sepsis, UTI | -- |
| 59 | 65 | M | 41 | Recurrent Pneumonia | -- |
| 60 | 43 | F | 44 | Recurrent and chronic HSV2 infection | Hypothyroidism |
| 61 | 71 | F | 30 | Chronic Fatigue | ANA 1:160 |
| 62 | 57 | M | 58 | Varicella, Mycobacterium tuberculosis | Pemphigus Vulgaris |